He has been working at Department of Endocrinology and Metabolism, 1st
Faculty of Medicine, Charles University in Prague since 1979, in the field of diabetes mellitus. The main topic of his interest are vascular complications in diabetes, their biochemistry and biomarkers. He has been a member of scientific organizations: Czech Diabetes Society (Secretary, President and Vice-chairman), Czech Medical Association (Vice-President), European Association for the Study of Diabetes (Secretary of the Postgraduate Education Subcommittee, Honorary Treasurer), and others. He represents Czech Medical Association in the UEMS. He is Vice-Rector of Charles University.